Results: Body weight loss was significantly higher (P<0.05) in those groups supplemented with α-lipoic acid. Get the latest public health information from CDC: https://www.coronavirus.gov. 2018 Apr;37(2):419-428. doi: 10.1016/j.clnu.2017.06.002. Alpha-lipoic acid may help you reduce weight. Source: 1 “Effects of α-lipoic acid and eicosapentaenoic acid in overweight and obese women during weight loss.” Obesity (Silver Spring). “The effect of lipoic acid supplements on blood lipids was limited,” said Gerd Bobe, another LPI scientist who collaborated on the study. 2020 Sep 20;12(9):2873. doi: 10.3390/nu12092873. 12 studies were analyzed and it was discovered that those who are taking the alpha-lipoic acid 300 mg supplements have lost an average of 1.52 lbs. Effects of oral α-lipoic acid administration on body weight in overweight or obese subjects: a crossover randomized, double-blind, placebo-controlled trial. The material appearing on LIVESTRONG.COM is for educational use only. Studies have suggested anti-obesity properties of ALA; however, results are inconsistent. LIVESTRONG.com may earn compensation through affiliate links in this story. Alpha-lipoic acid supplement in obesity treatment: A systematic review and meta-analysis of clinical trials. Alpha Lipoic Acid is hydrophilic and lipophilic (amphipathic), which allows it to reach every part of cells, including the mitochondria. EPA supplementation significantly attenuated (P<0.001) the decrease in leptin levels that occurs during weight loss. 2019 Jun 12;2019:3276958. doi: 10.1155/2019/3276958. Advocates of ALA make claims that range from beneficial effects for treating conditions such as diabetes and HIV to enhancing weight loss. Copyright Policy (iv.111)However, currently there is considerable disagreement amongst researchers about the benefits of using antioxidant supplements with an exercise program. Alpha-lipoic acid in the treatment of diabetic peripheral and cardiac autonomic neuropathy. . A significant overall mean BMI difference of -0.43 kg/ m2 (confidence interval = -0.82 to -0.03) was found between the ALA and placebo groups. According to studies, alpha-lipoic acid benefits health by helping to promote weight loss. Alpha-lipoic acid reacts with oxygen radicals that protect cell membranes, protect against LDL oxidation and modulation of hypertension. Leaf Group Ltd.  |  Understanding the Associations between Dietary Antioxidants and Obesity. In supplement form, it has long been taken to improve glucose sensitivity and treat diabetes, but more recently attention has moved to its potential for weight loss … Alpha-lipoic acid’s ability to enhance calorie burning and promote weight loss has been exaggerated by many diet gurus and supplements manufacturers. Alpha-lipoic acid can help you lose weight according to scientific research. , J Obes Metab Syndr. The supplement speeded up weight loss, as the figure below shows. 2020 Jul 2;11:694. doi: 10.3389/fphys.2020.00694. Alpha-lipoic acid supplementation significantly reduces the risk of obesity in an updated systematic review and dose response meta-analysis of randomised placebo-controlled clinical trials. These include Amanita mushroom poisoning, glaucoma , kidney disease , migraines , and peripheral arterial disease. A systematic review and meta-analysis of α-lipoic acid in the treatment of diabetic peripheral neuropathy. This added substance is giving individuals a boost when they need it the most, from something that is made within the human body already. The various drugs used to promote weight loss, as well as many dietary supplements for the same, are fraught with both efficacy and safety issues. It serves vital functions at the cellular level, such as energy production. J Nutr. In the weight-loss studies alpha-lipoic acid supplementation combined with a low calorie diet. Meta-regression analysis showed no significance in ALA dose on BMI and weight changes. After participants took 600 mg of the lipoic acid for a period of 24 weeks, “The data clearly showed a loss in body weight and body fat in people taking lipoic acid supplements,” said Balz Frei, director emeritus of OSU’s Linus Pauling Institute and one of the scientists on the study. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. A significant overall mean BMI difference of -0.43 kg/ m 2 (confidence interval = -0.82 to … The weight-loss enhancing ability of alpha lipoic acid has been put to the test in human studies as well. Conclusions: and Okanovic, A., Prnjavorac, B., Jusufovic, E., & Sejdinovic, R. (2015, July 9). What is Alpha Lipoic Acid? Alpha-Lipoic Acid: Weight Loss, Other Benefits and Side Effects Written by Ryan Raman, MS, RD Alpha-lipoic acid is an organic compound that acts as a powerful antioxidant in your body. Mean body weight differences between ALA treatment and placebo, Figure 3. Always talk to your doctor before beginning to take dietary supplements. Watanabe M, Risi R, Masi D, Caputi A, Balena A, Rossini G, Tuccinardi D, Mariani S, Basciani S, Manfrini S, Gnessi L, Lubrano C. Nutrients. Centers for Disease Control and Prevention: Obesity, Journal of Nutrition; Alpha-lipoic Acid and Cardiovascular Disease; Stephanie Wollin, et al. Please enable it to take advantage of the complete set of features! Alpha-lipoic acid treatment coincided with a statistically significant 1.27 kg (confidence interval = 0.25 to 2.29) greater mean weight loss compared with the placebo group. 2020 Sep 30;29(3):163-165. doi: 10.7570/jomes20070. Potential conflicts of interest: Authors report no competing interests, Figure 1. Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases. Li N, Yan W, Hu X, Huang Y, Wang F, Zhang W, Wang Q, Wang X, Sun K. Clin Endocrinol (Oxf). The Effect of 600 mg Alpha-lipoic Acid Supplementation on Oxidative Stress, Inflammation, and RAGE in Older Adults with Type 2 Diabetes Mellitus. Mendoza-Núñez VM, García-Martínez BI, Rosado-Pérez J, Santiago-Osorio E, Pedraza-Chaverri J, Hernández-Abad VJ. A systematic review of 12 clinical trials shows study participants supplementing with alpha-lipoic acid lost, on average, 1.52 pounds (0.69 kg) more than the placebo group. Epub 2020 Mar 26. 1. Alpha lipoic acid (ALA) is a highly-potent antioxidant that is available as a dietary supplement. The purpose of this study is to conduct a meta-analysis of the effect of ALA on weight and body mass index (BMI). Using Alpha Lipoic acid to address the weight issue in hypothyroidism is a tried and tested method. Research has shown that alpha-lipoic acid may affect weight loss in several ways.. Even modest weight loss may be associated with health benefits. Lipoic acid (often called α-lipoic acid), also known as thioctic acid, is a naturally occurring compound that is also synthesized by humans. I typically recommend 3,000 mg EPA and DHA per day. advertisements are served by third party advertising companies. Sharifi-Rad M, Anil Kumar NV, Zucca P, Varoni EM, Dini L, Panzarini E, Rajkovic J, Tsouh Fokou PV, Azzini E, Peluso I, Prakash Mishra A, Nigam M, El Rayess Y, Beyrouthy ME, Polito L, Iriti M, Martins N, Martorell M, Docea AO, Setzer WN, Calina D, Cho WC, Sharifi-Rad J. Results: Alpha-lipoic acid treatment coincided with a statistically significant 1.27 kg (confidence interval = 0.25 to 2.29) greater mean weight loss compared with the placebo group. Alpha lipoic acid has been proven to help with weight loss and thyroid health, primarily in women. For example, it may help with appetite control. The antioxidant works by stimulating the body's ability to convert food into energy and is water soluble. Use of this web site constitutes acceptance of the LIVESTRONG.COM Alpha-lipoic acid does not generally cause serious side effects, according to a study published in "American Journal of Medicine". I've been using it for years in my practice. I had ben having electrical like tingling in lower legs … ALA has been used in supplement form to help in the treatment of diabetes, HIV, cancer, liver ailments, and has recently gained more popularity in the use of weight loss. COVID-19 is an emerging, rapidly evolving situation. She graduated with a bachelor‚Äôs degree in laboratory sciences from Helsinki Polytechnic in 2002 and is currently working on her doctoral degree in cell and molecular biology. used as a substitute for professional medical advice, 1997 Sep;46 Suppl 2:S62-6. Bobe G, Michels AJ, Zhang WJ, Purnell JQ, Woffendin C, Pereira C, Vita JA, Thomas NO, Traber MG, Frei B, Hagen TM. The number of Alpha Lipoic Acid ability as an antioxidant, making Alpha Lipoic Acid is considered as a potent antioxidant. Results: However, before using any supplements for your diet you should consult with your doctor first. Studies have noticed that it may reduce enzyme AMP-activated protein kinase (AMPK) activity. Epub 2012 Jul 25. NIH These weight loss pills send 20% more glucose to away from fat cells and into muscle cells - which helps with weight loss and building muscle as more energy is used during exercise and less stored away as fat. eCollection 2020. Epub 2017 Jun 8. Alpha lipoic acid (ALA) is a fatty acid which is often referred to as the ‘universal antioxidant'. To further clarify earlier ALA findings, researchers launched a 10-week study. In addition to neutralizing free radicals, Alpha Lipoic Acid can also bind to and disable heavy metals such as iron-free (free iron), cadmium, magnesium, copper, mercury, zinc, nickel, cobalt, arsenic, manganese and lead. more than the group who were asked to take a placebo. Obesity is a serious health condition that has been increasing considerably since the 1980s in the United States. Another study published in "Current Pharmaceutical Design" in 2010, showed that a dose of 800 mg per day for four months cause a weight loss between 8 and 9 nine percent of body weight in obese or pre-obese teens. Obesity is a serious health condition that has been increasing considerably since the 1980s in the United States. 2012 Oct;167(4):465-71. doi: 10.1530/EJE-12-0555. The LIVESTRONG Foundation and LIVESTRONG.COM do not endorse Study duration significantly affected BMI change, but not weight change. Alpha-lipoic acid; body mass; diabetes; thioctic acid. Alpha lipoic acid (ALA) is a fatty acid that occurs naturally in the body and serves vital functions at the cellular level, such as energy production. In addition, many alternative practitioners contend that alpha-lipoic acid can prevent or treat a multitude of health conditions, including alcoholic liver disease, HIV, Alzheimer's disease, bipolar disorder, cardiac arrhythmia, high blood pressure, rheumatoid arthritis, premature labor, schizoph… The participants were assigned to one of three groups. And if you want to add EPA, I recommend taking it in the form of fish oil so that you get a dose of the essential fatty acid DHA at the same time. 2020 Sep 1;150(9):2336-2345. doi: 10.1093/jn/nxaa203. Maria Parepalo began writing professionally in 2006 and has published in medical journals as well as online. 2020 Jun;74(6):e13493. Studies of alpha-lipoic acid examined its properties as a supplement to reduce the risk of cardiovascular disease and as a possible supplement for weight loss. Mean body weight differences between…, Figure 2. R01 DK093924/DK/NIDDK NIH HHS/United States. Leptin has also garnered quite a bit of interest in the field of weight loss studies. It should not be (More information) 2. Despite the positive research results, alpha-lipoic acid is not a miracle pill that will make you lose weight on its own. A comprehensive, systematic literature search identified 10 articles on randomized, double-blind, placebo-controlled studies involving ALA. We conducted a meta-analysis of mean weight and BMI change differences between ALA and placebo treatment groups. Moreover, we do not select every advertiser or advertisement that appears on the web site-many of the As long as you're healthy, the body can produce all the ALA it needs for these purposes. New Data on Alpha Lipoic Acid. Alpha-lipoic acid (ALA) is a naturally occurring antioxidant. 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